Fluorochemicals used in food packaging inhibit male sex hormone synthesis.
Source
Division of Toxicology & Risk Assessment, National Food Institute, Technical University of Denmark, DK-2860 Søborg, Denmark. akjro@food.dtu.dk
Abstract
Polyfluoroalkyl phosphate surfactants (PAPS) are widely used in food contact materials (FCMs) of paper and board and have recently been detected in 57% of investigated materials. Human exposure occurs as PAPS have been measured in blood; however knowledge is lacking on the toxicology of PAPS. The aim of this study was to elucidate the effects of six fluorochemicals on sex hormone synthesis and androgen receptor (AR) activation in vitro. Four PAPS and two metabolites, perfluorooctanoic acid (PFOA) and 8:2 fluorotelomer alcohol (8:2 FTOH) were tested. Hormone profiles, including eight steroid hormones, generally showed that 8:2 diPAPS, 8:2 monoPAPS and 8:2 FTOH led to decreases in androgens (testosterone, dehydroepiandrosterone, and androstenedione) in the H295R steroidogenesis assay. Decreases were observed for progesterone and 17-OH-progesterone as well. These observations indicated that a step prior to progestagen and androgen synthesis had been affected. Gene expression analysis of StAR, Bzrp, CYP11A, CYP17, CYP21 and CYP19 mRNA showed a decrease in Bzrp mRNA levels for 8:2 monoPAPS and 8:2 FTOH indicating interference with cholesterol transport to the inner mitochondria. Cortisol, estrone and 17β-estradiol levels were in several cases increased with exposure. In accordance with these data CYP19 gene expression increased with 8:2 diPAPS, 8:2 monoPAPS and 8:2 FTOH exposures indicating that this is a contributing factor to the decreased androgen and the increased estrogen levels. Overall, these results demonstrate that fluorochemicals present in food packaging materials and their metabolites can affect steroidogenesis through decreased Bzrp and increased CYP19 gene expression leading to lower androgen and higher estrogen levels.
Kajian in vitro ini mendapati bahan fluorochemicals yang terdapat pada pembungkus makanan boleh menyebabkan penurunan hormon androgen yang membentuk sifat lelaki dan meningkatkan aras hormon estrogen yang membentuk ciri keperempuanan. Bahan ini digunakan dalam pembungkus makanan supaya ia menjadi tidak telap air dan minyak. Pembungkus ringkas ini boleh kita dapati dengan banyak samada digunakan diindustry pempungkusan makanan, pembungkus makanan segera atau mungkin juga kertas bergris yang kita guna untuk nasi lemak, mee goreng dan nasi campur? Adakah ia menyumbang kepada peningkatan pasangan yang sukar mendapat anak? Atau mungkin kepada peningkatan lelaki lembut?
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